Does Obesity Modify the Ability of Prebiopsy Prostate Specific Antigen to Detect Prostate Cancer on Repeat Biopsy? Results from the REDUCE Study
作者： Adriana C. Vidal , Lauren E. Howard , Daniel M. Moreira , Ramiro Castro-Santamaria , Gerald L. Andriole
DOI: 10.1016/J.JURO.2015.01.111
关键词: Dutasteride 、 Body mass index 、 Biopsy 、 Urology 、 Obesity 、 Medicine 、 Prostate cancer 、 PCA3 、 Prostate-specific antigen 、 Overweight 、 Oncology 、 Internal medicine
摘要: Purpose: Higher body mass index is linked to lower prostate specific antigen. This has given rise concerns that antigen may be less reliable for predicting cancer among obese men. We tested the accuracy of prebiopsy across categories.Materials and Methods: used REDUCE study, which dutasteride risk reduction in men with a 2.5 to 10.0 ng/ml negative pre-study biopsy. All were required have biopsy at 2 4 years independent assessed performance predict overall high grade (Gleason sum 7 or greater) each group using AUC.Results: Of 6,103 who had 2-year 1,646 (27%) normal weight, 3,209 (53%) overweight 1,248 (20%) obese. Mean adjusted overw...
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