The inverse relationship between prostate specific antigen (PSA) and obesity

摘要: Obese men have lower serum prostate-specific antigen (PSA) than comparably aged lean men, but the underlying mechanism remains unclear. The aim of this study was to determine effect obesity on PSA and potential contributing mechanisms. A cohort 1195 35 years over at recruitment, with demographic, anthropometric (BMI, waist circumference (WC)) hormone (serum testosterone, estradiol (E2)) hematology assessments obtained two waves assessed. Men a history prostate cancer or missing were excluded, leaving 970 for final analysis. Mixed-effects regressions mediation analyses adjusting hormonal volumetric factors explore mechanisms relating PSA. After age, levels in greater WC (P = 0.001). In multivariable model including WC, E2/testosterone PlasV as predictors, no statistically significant associations observed between either 0.36) 0.49), while strong both < 0.001) age mediator, average causal (ACME) explained roughly 20% total 0.31), when is ACME 50% Our findings indicate that obese compared normal weight can be by changes (elevated ratio) hemodilution. Hormonal therefore represent substantial underappreciated mediating pathway.