Does obesity affect the accuracy of prostate-specific antigen (PSA) for predicting prostate cancer among men undergoing prostate biopsy

摘要: What's known on the subject? and What does study add? As most urologist known, obesity significantly lowers serum PSA levels. So there is some concern about delayed diagnosis of prostate cancer in obese men. In present study, we found that accuracy level for detecting was not different between A well-designed adjusting several factors, e.g. diet, exercise, medication comorbidity, which may possibly compensate associated effects levels, needed confirmation findings. Objective To investigate prostate-specific antigen (PSA) according to body mass index (BMI) Asian men with a <30 ng/mL using contemporary multicore (≥12) biopsy. Patients Methods We reviewed records 3471 patients, whose initial levels were <30 ng/mL, who underwent transrectal ultrasound-guided biopsy January 2004 May 2011. BMI categorised as performed previously population: <23, 23–24.9, 25–29.9, ≥30 kg/m2. each BMI group assessed based receiver operating characteristics-derived area under curve. Results The mean age median inversely BMI; category 7.84, 7.75, 7.33 5.79 ng/mL, respectively (P < 0.001). In all, detected from 1102 (31.7%) patients. The predicting all patients estimated be 0.607, accuracies 0.638, 0.572, 0.613 0.544, respectively; no significant difference among groups terms accuracy. Conclusions The did change regardless men. However, higher BMIs had lower than those BMIs, it can therefore suggested threshold should discriminate benign conditions real clinical situation.