Effects of activin-A, inhibin-A, and transforming growth factor-beta 1 on stage-specific deoxyribonucleic acid synthesis during rat seminiferous epithelial cycle.
作者： H Hakovirta , A Kaipia , O Söder , M Parvinen
DOI: 10.1210/ENDO.133.4.8404607
关键词: Endocrinology 、 Germ cell 、 Spermatogenesis 、 Transforming growth factor beta 、 TGF beta 1 、 Seminiferous tubule 、 Internal medicine 、 DNA synthesis 、 TGF beta signaling pathway 、 Biology 、 Activin and inhibin
摘要: Activin and inhibin are members of the transforming growth factor-beta (TGF beta) gene family. They expressed in various organ systems, where they possess regulatory functions. Inhibin, activin, TGF beta have been reported to also be adult rat testis. We studied vitro action these factors on premitotic premeiotic DNA synthesis during seminiferous epithelial cycle. Two-millimeter tubule segments were isolated by transillumination-assisted microdissection from stages V, VIIa, VIII-IX, I cycle incubated presence activin-A, inhibin-A, or 1. During 24-, 48-, 72-h incubation spontaneous progression spermatogenesis was noted. The staged samples allowed us selectively quantitate synthetic activity specific germ cell types. At end culture, tubules pulse labeled with [3H]thymidine, quantified liquid scintillation counting, activated c...
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