Antimalarial Activity of Artemisinin (Qinghaosu) and Related Trioxanes: Mechanism (s) of Action
作者： Jared N. Cumming , Poonsakdi Ploypradith , Gary H. Posner
DOI: 10.1016/S1054-3589(08)60952-7
关键词: Plasmodium falciparum 、 Drug resistance 、 Artemisinin 、 Mechanism of action 、 Biology 、 Plasmodium 、 Pharmacology 、 Mode of action 、 Artemisinins 、 Malaria
摘要: … reactive intermediates—cytotoxic free radicals, one or more high-valent iron-oxo intermediates, and electrophilic alkylating agents—that ultimately cause fatal damage to the parasites. …
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