Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development.
作者： Zena Werb , Ole Behrendtsen , Alasdair MacAuley , Babette S. Heyer
关键词: Cell biology 、 Biology 、 Germ cell 、 Cell cycle 、 Cell cycle checkpoint 、 DNA damage 、 Apoptosis 、 Embryonic stem cell 、 Embryo 、 Progenitor cell
摘要: Gastrulation in mice is associated with the start of extreme proliferation and differentiation. The potential cost to embryo a very rapid rate high production damaged cells. We demonstrate novel surveillance mechanism for elimination cells by ionizing radiation during mouse gastrulation. During this restricted developmental window, becomes hypersensitive DNA damage induced low dose irradiation (<0.5 Gy) undergoes apoptosis without cell cycle arrest. Intriguingly, embryonic cells, including germ progenitors, but not extraembryonic become genotoxic stress undergo Atm- p53-dependent apoptosis. Thus, hypersensitivity early fate-dependent ensure genomic integrity period
sci-hub.st 参考文章(52)
K. A. Lawson, W. J. Hage, Clonal analysis of the origin of primordial germ cells in the mouse. Ciba Foundation symposium. ,vol. 182, pp. 68- 91 ,(2007) , 10.1002/9780470514573.CH5
Richard A. Woo, Kevin G. McLure, Susan P. Lees-Miller, Derrick E. Rancourt, Patrick W. K. Lee, DNA-dependent protein kinase acts upstream of p53 in response to DNA damage Nature. ,vol. 394, pp. 700- 704 ,(1998) , 10.1038/29343
Gretchen S Jimenez, Fredrik Bryntesson, Maria I Torres-Arzayus, Anne Priestley, Michelle Beeche, Shin'ichi Saito, Kazuyasu Sakaguchi, Ettore Appella, Penny A Jeggo, Guillermo E Taccioli, Geoffrey M Wahl, Michael Hubank, None, DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage Nature. ,vol. 400, pp. 81- 83 ,(1999) , 10.1038/21913
A. McLaren, M.H. Snow, M. Ginsburg, Primordial germ cells in the mouse embryo during gastrulation. Development. ,vol. 110, pp. 521- 528 ,(1990) , 10.1242/DEV.110.2.521
G.R. Martin, M. Boyle, J.M. Hebert, mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation. Development. ,vol. 112, pp. 407- 415 ,(1991) , 10.1242/DEV.112.2.407
P. W. J. Rigby, C.-T. J. Chan, M. J. Evans, E. J. Robertson, P. M. Timmons, F. Poirier, The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo Development. ,vol. 113, pp. 1105- 1114 ,(1991) , 10.1242/DEV.113.4.1105
J.F. Ward, DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 35, pp. 95- 125 ,(1988) , 10.1016/S0079-6603(08)60611-X
Dale L. Ludwig, Mark A. MacInnes, Yuichi Takiguchi, Paige E. Purtymun, Melinda Henrie, Margaret Flannery, Juanito Meneses, Roger A. Pedersen, David J. Chen, A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity Mutation Research-dna Repair. ,vol. 409, pp. 17- 29 ,(1998) , 10.1016/S0921-8777(98)00039-1
Shasha Wang, Alla Godelman, Sundeep Kalantry, Karen Witty-Blease, Victor De Leon, William S. Chen, Elizabeth Lacy, Rosemary F. Bachvarova, Katia Manova, Carol Tomihara-Newberger, Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice. Developmental Dynamics. ,vol. 213, pp. 293- 308 ,(1998) , 10.1002/(SICI)1097-0177(199811)213:3<293::AID-AJA6>3.0.CO;2-D
Michael B. Kastan, Qimin Zhan, Wafik S. El-Deiry, France Carrier, Tyler Jacks, William V. Walsh, Beverly S. Plunkett, Bert Vogelstein, Albert J. Fornace, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia Cell. ,vol. 71, pp. 587- 597 ,(1992) , 10.1016/0092-8674(92)90593-2