GFR is better estimated by considering both serum cystatin C and creatinine levels
作者： Yann Bouvet , François Bouissou , Yvon Coulais , Sophie Séronie-Vivien , Mathieu Tafani
DOI: 10.1007/S00467-006-0145-Z
关键词: Population 、 Medicine 、 Confidence interval 、 NONMEM 、 Urology 、 Cystatin C 、 Pharmacokinetics 、 Renal function 、 Endocrinology 、 Internal medicine 、 Creatinine 、 Covariate 、 Pediatrics, Perinatology, and Child Health 、 Nephrology
摘要: Serum cystatin C (cysC) is a potential marker of the glomerular filtration rate (GFR) that has generated conflicting reports in children. A prospective study was conducted to assess benefit considering cysC together with serum creatinine (SCr) and demographic morphologic characteristics better estimate 51Cr-ethylenediaminetetraacetate (EDTA) clearance (CL), i.e., GFR. Plasma 51Cr-EDTA data from 100 children or young adults (range: 1.4–22.8 years old) were analyzed according population pharmacokinetic approach by using nonlinear mixed effects model (NONMEM) program. The actual CL compared predicted different covariate equations. best equation (±95% confidence interval) was: GFR (ml/min)=63.2(±3.4) . [(SCr (μM)/96)−0.35 (±0.20)] [(cysC (mg/l)/1.2)−0.56 (±0.19)] [(body weight (kg)/45)0.30 (±0.17)] [age (years)/14)0.40 (±0.16)]. This associated less biased more precise estimation than Schwartz equation. CysC improves if considered other covariates within mathematical formula.
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