Estimation of the glomerular filtration rate in children: which algorithm should be used?
作者： Lyonne K. van Rossum , Ron A. A. Mathot , Karlien Cransberg , Robert Zietse , Arnold G. Vulto
DOI: 10.1007/S00467-005-2001-Y
关键词:
摘要: Glomerular filtration rate (GFR) in children can be estimated by the formula GFR=k×BH/Pcr (where BH is body height centimetres and Pcr plasma creatinine concentration micromoles per litre). For k, several values have been reported: k=38 (Counahan), k=40 (Morris) k=48.7 (Schwartz). In this study predictive performance of these formulae was compared with that newly developed formulae. GFR measurements based on inulin time curves were divided into an index (n=58) a validation data set (n=48). value for k derived application nonlinear mixed-effect modelling. This approach also used to develop better explained relationship between patient factors GFR. Bias precision all calculated set. 41.2 found which close (Morris). Both well (bias <5%; 25%). Further modelling did not improve performance. our hospital best k=41.2. It recommended optimal assessed locally.
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