Pillars Article: Development of TH1 CD4+ T Cells Through IL-12 Produced by Listeria-Induced Macrophages. 1993. Science 260(5107): 547–549

摘要: Development of the appropriate CD4 + T helper (T H ) subset during an immune response is important for disease resolution. With use naive, ovalbumin-specific αβ cell receptor transgenic cells, it was found that heat-killed Listeria monocytogenes induced 1 development in vitro through macrophage production interleukin-12 (IL-12). Moreover, inhibition IL-12 may explain ability IL-10 to suppress development. Murine responses L. vivo are phenotype. Therefore, this regulatory pathway have evolved enable innate interactions with microbial pathogens, direct specific immunity toward