Rifamorpholines A–E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4
作者： Yong Sheng Xiao , Bo Zhang , Mei Zhang , Zhi Kai Guo , Xin Zhao Deng
DOI: 10.1039/C7OB00614D
关键词: Chemistry 、 Rifamycin 、 Locust 、 Microbiology 、 Actinobacteria 、 Amycolatopsis sp. 、 Morpholine 、 Staphylococcus aureus 、 Antibiotics 、 Crystallographic data
摘要: Cultivation of locust associated rare actinobacteria, Amycolatopsis sp. HCa4, has provided five unusual macrolactams rifamorpholines A-E. Their structures were determined by interpretation spectroscopic and crystallographic data. Rifamorpholines A-E possess an unprecedented 5/6/6/6 ring chromophore, representing a new subclass rifamycin antibiotics. The biosynthetic pathway for compounds 1-5 involves key 1,6-cyclization the formation morpholine ring. Compounds 2 4 showed potent activities against methicillin-resistant Staphylococcus aureus (MRSA) with MICs 4.0 8.0 μM, respectively.
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