Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete.
作者： Shi Ying Ma , Yong Sheng Xiao , Bo Zhang , Fen Li Shao , Zhi Kai Guo
DOI: 10.1021/ACS.ORGLETT.7B03113
关键词:
摘要: Two novel enediyne-derived natural products, amycolamycins A and B (1 2), were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins contain unique 2-(cyclopenta[a]inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing analysis of the acm gene cluster allowed us to propose pathway 1 2. Moreover, amycolamycin (1) was selectively cytotoxic M231 breast cancer cell line.
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