Renal cortical blood flow and glomerular filtration in myohemoglobinuric acute renal failure

摘要: Renal cortical blood flow and glomerular filtration in myohemoglobinuric acute renal failure.Renal measurements were made serially after the induction of failure water-drinking rats others given 150 mM saline for a month place drinking water.Blood both groups fell to some one-third control first two hours injection.Cortical perfusion water stabilized at approximately 24% 24 hour study period, but rose rapidly 85% saline-drinking group.Glomerular (GFR) animals was too slow accurate measurement.GFR improved concomitantly with animals, reaching 84% within 12 hours.Estimations intra-glomerular pressure various rates calculated pre- postglomerular resistances suggested that primarily attributable preglomerular vascular resistance change.A small decrease could not be ruled out, however.In recovery, increased still chiefly responsible any residual deficit flow, an inhomogeneity nephron found earlier, and/or element relaxation, lowered below predicted on basis constriction alone.Long-term loading prior myohemoglobinuria appears prevent by abolishing sustained ischemia.