Increased Expression of Brain-Derived Neurotrophic Factor Transcripts I and VI, cAMP Response Element Binding, and Glucocorticoid Receptor in the Cortex of Patients with Temporal Lobe Epilepsy

摘要: A body of evidence supports a relevant role brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cerebral atrophy extends to regions are functionally and anatomically connected with hippocampus, especially cortex. We previously reported an increased expression BDNF messenger for exon VI hippocampus patients compared autopsy control group. Altered levels this particular transcript were also associated pre-surgical use certain psychotropic. extended here our analysis transcripts I, II, IV, cortex since region holds intrinsic communication is structurally affected TLE. assayed cyclic adenosine monophosphate response element-binding (CREB) glucocorticoid receptor (GR) genes as there experimental changes their epilepsy. TLE pharmacological treatment considered primary clinical independent variables. Transcripts I pharmacoresistant The CREB GR follow same direction. Pre-surgical selective serotonin reuptake inhibitors, carbamazepine (CBZ) valproate (VPA), was differential specific genes. These could have functional implication plasticity mechanisms related