The Impact of IL-16 3′UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals

摘要: Lung carcinoma is the most common cancer and cause of deaths among both males females in China. Previously, genetic variants located gene untranslated region have been well established as interfering factors mRNA translation confirmed playing critical roles lung oncogenesis. However, correlation between polymorphisms 3′ risk less reported China Han population. In this study, 3′-untranslated IL-16, CYP24A1, FBN1 were determined 322 patients 384 healthy controls with usage Sequenom MassARRAY. The selected was examined by unconditional logistic regression analysis or without adjustments for age, gender, smoking status, alcohol drinking status. Additionally, stratification applied to detect associations SNPs different subgroups. As results, significant relationships found IL-16 rs859 susceptibility recessive model (OR= 0.65, 95% CI: 0.44-0.96, P= 0.029) log-additive 0.76, 0.60-0.96, 0.019). Moreover, adjusted stratified also revealed important effects on individuals aged older than 50, males, nondrinkers. showed statistically evidence associated adenocarcinoma small cell Chinese population well. Our research demonstrated that variant 3′UTR result might be exploited a new biomarker assessment prevention.