Chemoattractant mechanism of Th1 cells in class III and IV lupus nephritis
作者： Shinji Morimoto , Yoshiaki Tokano , Souichiro Nakano , Takashi Watanabe , Yoshihiro Tamayama
DOI: 10.1080/08916930802438790
关键词: Immunology 、 Interferon 、 Pathogenesis 、 Flow cytometry 、 Chemotaxis 、 Biology 、 Monocyte 、 In vitro 、 Lupus nephritis 、 Chemokine
摘要: Proliferative lupus nephritis (PLN) is the common, severe, and important form of nephritis. Recent report showed that T cells producing Interferon (IFN)gamma (Th1 cells) increased in patients with World Health Organization class IV. However, relation between increase Th1 pathogenesis has been made unclear. The aim this study was to examine chemoattractant mechanism Th1-producing whether vitro IFNgamma secretion from PLN. Th1:Th2 ratio peripheral blood measured by flow cytometry. serum levels IL-2, IFNgamma, IL-13, monocyte protein-1 (MCP-1) IP-10 were determined using enzyme-linked immunosorbent assay. In production assay, CD4(+)T co-cultured IL-12 and/or IL-18. PLN high not correlated cytokine level. This cell tended go toward inflammatory lesion low CD62L expression chemokines. level MCP-1 significantly increased. Lastly, produced addition IL-18, while normal controls did produce. These findings suggest combination inducers chemokine inhibition might be powerful threrapeutic approach
informahealthcare.com参考文章(37)
The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. QJM: An International Journal of Medicine. ,vol. 72, pp. 779- 833 ,(1989) , 10.1093/OXFORDJOURNALS.QJMED.A068371
I. Sekigawa, T. Naito, Y. Tokano, H. Kaneko, Y. Takasaki, H. Ogasawara, S. Lee, S.-I. Hirose, T. Hishikawa, H. Akimoto, H. Hashimoto, Circulating levels of beta-chemokines in systemic lupus erythematosus. The Journal of Rheumatology. ,vol. 26, pp. 568- 573 ,(1999)
Gerald B. Appel, David J. Cohen, Conrad L. Pirani, Jay I. Meltzer, Dorothy Estes, Long-term follow-up of patients with lupus nephritis The American Journal of Medicine. ,vol. 83, pp. 877- 885 ,(1987) , 10.1016/0002-9343(87)90645-0
Mimi L. K. Tang, Xiu-Qin Zhang, Thomas F. Tedder, Douglas A. Steeber, Intrinsic Differences in L-Selectin Expression Levels Affect T and B Lymphocyte Subset-Specific Recirculation Pathways Journal of Immunology. ,vol. 160, pp. 5113- 5121 ,(1998)
Y. TOKANO, S. MORIMOTO, H. KANEKO, H. AMANO, K. NOZAWA, Y. TAKASAKI, H. HASHIMOTO, Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE)—relation to Th1- and Th2-derived cytokines Clinical and Experimental Immunology. ,vol. 116, pp. 169- 173 ,(1999) , 10.1046/J.1365-2249.1999.00862.X
Craig Gerard, Barrett J. Rollins, Chemokines and disease Nature Immunology. ,vol. 2, pp. 108- 115 ,(2001) , 10.1038/84209
Konstantinos A. Papadakis, Daocheng Zhu, John L. Prehn, Carol Landers, Armine Avanesyan, Gina Lafkas, Stephan R. Targan, Dominant Role for TL1A/DR3 Pathway in IL-12 plus IL-18-Induced IFN-γ Production by Peripheral Blood and Mucosal CCR9+ T Lymphocytes The Journal of Immunology. ,vol. 174, pp. 4985- 4990 ,(2005) , 10.4049/JIMMUNOL.174.8.4985
Ehsanollah Esfandiari, Iain B. McInnes, George Lindop, Fang-Ping Huang, Max Field, Mousa Komai-Koma, Xiao-qing Wei, Foo Y. Liew, A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease Journal of Immunology. ,vol. 167, pp. 5338- 5347 ,(2001) , 10.4049/JIMMUNOL.167.9.5338
Jean-Marc Gauguet, Steven D. Rosen, Jamey D. Marth, Ulrich H. von Andrian, Core 2 branching β1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes Blood. ,vol. 104, pp. 4104- 4112 ,(2004) , 10.1182/BLOOD-2004-05-1986
Maria L. Arbonés, David C. Ord, Klaus Ley, Howard Ratech, Catherine Maynard-Curry, Gib Otten, Daniel J. Capon, Thomas F. Teddert, Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice Immunity. ,vol. 1, pp. 247- 260 ,(1994) , 10.1016/1074-7613(94)90076-0