Experimental Stressors Alter Hypertonic Saline-Evoked Masseter Muscle Pain and Autonomic Response

作者: Lene Baad-Hansen , Karina Haugaard Bendixen , Astrid Juhl Terkelsen , Peter Svensson , Brian E Cairns

DOI:

关键词: Cold pressor testAnesthesiaAnalysis of varianceHemodynamicsMasseter muscleHypertonic salineHeart ratePsychologyRandomized controlled trialHeart rate variability

摘要: Aims: To test in a randomized controlled trial, if hypertonic saline (HS)–evoked pain and autonomic function are modulated by either cold pressor (CPT) or mental arithmetic stress induced paced auditory serial addition task (PASAT). Methods: Fourteen healthy women participated three sessions. Pain was two 5% HS infusions (5 minutes each, 30 apart) infused into the masseter muscle. During second infusion, PASAT, CPT, control (HS alone). HS-evoked intensity scored on 0 to 10 numeric rating scale (NRS). Heart rate variability (HRV) hemodynamic measures were recorded noninvasively (Task Force Monitor). Data analyzed using repeated measurements ANOVAs Spearman correlation analysis. Results: significantly similarly reduced both PASAT (30.8 ± 27.6%; P .05). CPT increased heart compared with (P Conclusion: muscle altered response. The increase following may be caused different mechanisms. of efferent cardiac vagal (parasympathetic) activity, while PASAT-induced rate, but unchanged HRV, suggest neurohumoral activation. J OROFAC PAIN 2012;26:191–205

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