OCA-B regulation of B-cell development and function
关键词: Signal transduction 、 Cytoplasm 、 Cell biology 、 Gene expression 、 Gene isoform 、 Trans-Activators 、 Molecular biology 、 Germinal center 、 Humoral immune deficiency 、 Biology 、 B cell 、 Immunology
摘要: The transcriptional co-activator OCA-B [for Oct from B cells, also known as OBF-1 (OCT-binding factor-1) and Bob1] is not required for B-cell genesis but does regulate subsequent development function. deficient mice show strain-specific, partial blocks at multiple stages of maturation a complete disruption germinal center formation in all strains, causing humoral immune deficiency susceptibility to infection. probably exerts its effects through the regulation octamer-motif controlled gene expression. encodes two proteins distinct molecular weight, designated p34 p35. isoform localizes nucleus, whereas p35 myristoylated bound cytoplasmic membrane. can traffic nucleus activates octamer-dependent transcription, although this might cells membrane-related signal transduction.
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