Multidimensional hydrogel models reveal endothelial network angiocrine signals increase glioblastoma proliferation, invasion, and temozolomide resistance

摘要: Glioblastoma is the most common primary malignant brain tumor. The tissue microenvironment adjacent to vasculature, termed perivascular niche, has been implicated in promoting biological processes involved glioblastoma progression such as invasion, proliferation, and therapeutic resistance. However, exact nature of cues that support tumor cell aggression this niche are largely unknown. Soluble angiocrine factors secreted by tumor-associated vasculature have shown behaviors other cancer types. Here, we exploit macroscopic microfluidic gelatin hydrogel platforms profile self-assembled endothelial networks evaluate their relevance biology. Aggregate U87-MG migration, resistance temozolomide. We also identify a novel role for TIMP1 facilitating migration. Overall, work highlights use multidimensional models signals progression.