Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

作者: A Satyanarayana , P Kaldis

DOI: 10.1038/ONC.2009.170

关键词: Gene knockoutCell cycleMitotic cell cycleCyclin-dependent kinase 2Cell biologyCyclinBiologyCyclin-dependent kinaseCyclin-dependent kinase 1Knockout mouse

摘要: … Several unexpected compensatory mechanisms were uncovered among cyclins and Cdks in these … Here we review the compensatory mechanisms among major cyclins and Cdks in …

参考文章(123)
P M O'Connor, Mammalian G1 and G2 phase checkpoints Cancer surveys. ,vol. 29, pp. 151- 182 ,(1997)
Dong Liu, Martin M. Matzuk, Weng Kong Sung, Qiuxia Guo, Pei Wang, Debra J. Wolgemuth., Cyclin A1 is required for meiosis in the male mouse Nature Genetics. ,vol. 20, pp. 377- 380 ,(1998) , 10.1038/3855
Patrick Meraldi, Jiri Lukas, Andrew M. Fry, Jiri Bartek, Erich A. Nigg, Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nature Cell Biology. ,vol. 1, pp. 88- 93 ,(1999) , 10.1038/10054
Sushil G. Rane, Pierre Dubus, Richard V. Mettus, Elizabeth J. Galbreath, Guenther Boden, E. Premkumar Reddy, Mariano Barbacid, Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nature Genetics. ,vol. 22, pp. 44- 52 ,(1999) , 10.1038/8751
M. Pagano, R. Pepperkok, F. Verde, W. Ansorge, G. Draetta, Cyclin A is required at two points in the human cell cycle. The EMBO Journal. ,vol. 11, pp. 961- 971 ,(1992) , 10.1002/J.1460-2075.1992.TB05135.X
Sasha Akoulitchev, Sergei Chuikov, Danny Reinberg, TFIIH is negatively regulated by cdk8-containing mediator complexes Nature. ,vol. 407, pp. 102- 106 ,(2000) , 10.1038/35024111
Martha J. Grossel, Peter Slomiany, David Krull, Karen K. Ericson, Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes. Molecular Cancer Research. ,vol. 1, pp. 654- 664 ,(2003)