Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study

摘要: Abstract Schizophrenia (SZ) is a heterogeneous disorder that presents in adolescence, persists into adulthood, and has many clinical features. Recent evidence suggests abnormalities inflammatory, neurotrophic, angiogenic processes may play role the etiology of SZ. The identification molecular biomarkers early course disease crucial to transforming diagnostic therapeutic avenues. We investigated 14 analytes focusing on neurotrophic pathways from plasma antipsychotic-naive familial high risk for SZ (FHR; n = 35) first-episode psychosis (FEP; n = 45) subjects, comparison healthy controls (HC, n = 39). identified distinct alterations signatures young relatives at FHR prior onset FEP subjects. Firstly, expression soluble fms-like tyrosine kinase (sFlt-1), an anti-angiogenic factor binds vascular endothelial growth (VEGF), was significantly increased group compared HC, but not FEP. Secondly, interferon gamma (IFNγ) reduced HC. Thirdly, network analysis revealed positive correlation between sFlt-1 VEGF, suggesting activation cascade group, which Our results indicate angiogenesis immunological dysfunction disease, shifting balance towards anti-angiogenesis inflammation.