Cerebral ischemia-induced genes are increased in acute schizophrenia: An opportunity for clinical translation of genomic research findings

摘要: Schizophrenia is a brain disorder of unknown etiology. Brain imaging studies have revealed evidence for hypoperfusion the frontal cortex (hypofrontality) and progressive volume reduction in schizophrenic patients. Mild cerebral ischemia (oligemia) has been postulated as cause disorder. If hypothesis adult correct, genes induced by should be increased patients during acute psychosis. Here, we show first time through combined analysis gene expression data from all Stanley Collection covering Brodmann area 46 employing well-established Affymetrix HGU133a microarray platform that upregulated are significantly overexpressed (4.5-fold) (representation factor (RF) 4.5, p < 0.0002) to lesser degree chronic (RF 3.9, 0.008) comparison normal controls. Neurodevelopmental-, repair-, inflammation- synapse-related showed no significant change. The difference between regarding ischemia-induced was highly 2.8, 0.00007). results reported here line with biochemical, cellular, electroencephalographic, imaging, near-infrared spectroscopy, vascular, genetic association studies. In summary, our genomic clear ischemic signature schizophrenia patients, confirming prediction this This finding suggests new possibilities treatment prevention schizophrenia.