Hexokinase isoenzymes in tissues of the adult and developing guinea pig.

摘要: Abstract Changes in the activities and isoenzyme distribution of hexokinase were determined a number tissues during development guinea pig. The total activity fetal liver showed large fall second half gestation to reach adult values by term. With normal diet fetal, neonatal, livers had isoenzymes I III but little or no detectable IV (glucokinase). predominantly type I, proportion increased development. kinetics pig similar those reported for rat. Two additional with mobility between II detected blood. They appear have kinetic properties I. Detectable glucokinase was induced glucose administration pigs. kidney, brain skeletal muscle postnatal rise while heart it high declined after birth. These contained varying proportions hexokinase. ratio particulate-bound soluble varied from tissue tissue. All except significant increase binding changes are discussed relation control utilization neonatal periods.