Pseudoceramide for childhood eczema: does it work?

摘要: Objectives Atopic eczema is a chronic relapsing skin disease associated with atopy, and characterised by reduced hydration, impaired integrity (transepidermal water loss), poor quality of life. Proper emollient usage an important facet its management. This study aimed to establish approach evaluate the efficacy using over 4-week period. Design Prospective observational study. Setting A paediatric dermatology out-patient clinic university teaching hospital in Hong Kong. Patients Consecutive new patients aged 5 18 years atopic diagnosed according Hanifin Rajka's criteria were recruited from March August 2009. They or their parents instructed liberally apply test flexures areas affected eczema, twice daily. Outcome assessments repeated 2 4 weeks later. Main outcome measures Skin hydration transepidermal loss right forearm (2 cm below antecubital flexure), severity (SCORing Dermatitis index) Children's Dermatology Life Quality Index. At end period, global assessment treatment was recorded. Results Thirty-three treated applications pseudoceramide-containing cream (Curel, Kao, Japan). The mean age (16 males 17 females) 12 (standard deviation, 4) years. Four following use cream, improved significantly fewer topical corticosteroids. In these patients, there no deterioration loss, severity, Conclusion pseudoceramide but not life usage.