The matrix metalloproteinases as pharmacological target in osteoarthritis: statins may be of therapeutic benefit.

摘要: Osteoarthritis (OA) is a common joint disease; however, current pharmacologic agents for OA are only symptomatic and they can not prevent the disease progression. Matrix metalloproteinases (MMPs) produced by chondrocytes play an important role in development of cartilage destruction OA, that target against MMPs activity may be therapeutical value. There were reports statins inhibit secretion vitro vivo, which believed to account plaque stabilizing effects treatment atherosclerosis. We based our hypothesis on atherosclerosis possesses some aspects similar osteoarthritis, such as inflammation matrix degradation. Since have displayed great benefits modifying progression via anti-inflammatory matrix-stabilizing mechanisms, it conceivable also osteoarthritis. Further work needed verify if protect from through inhibition MMP chondrocytes, their potential used therapeutic should investigated.