Characterization and risk association of polymorphisms in Aurora kinases A , B and C with genetic susceptibility to gastric cancer development

摘要: Single nucleotide polymorphisms (SNPs) in genes encoding mitotic kinases could influence development and progression of gastric cancer (GC). Case-control study nine SNPs was conducted using qPCR. The included 116 GC patients 203 controls. In silico analysis performed to evaluate the effects on transcription factors binding sites. AURKA rs1047972 genotypes (CT vs. CC: OR, 1.96; 95% CI, 1.05–3.65; p = 0.033; CC + TT CT: 1.94; 1.04–3.60; p = 0.036) rs911160 (CC GG: 5.56; 1.24–24.81; p = 0.025; GG + CG 5.26; 1.19–23.22; p = 0.028), were associated with increased risk, whereas certain rs8173 (CG 0.60; 0.36–0.99; p = 0.049; GG 0.38; 0.18–0.79; p = 0.010; CC + CG 0.49; 0.25–0.98; p = 0.043) protective. Association risk demonstrated for AURKB rs2241909 (GG + AG AA: 1.61; 1.01–2.56; p = 0.041) rs2289590 (AC 2.41; 1.47–3.98; p = 0.001; CC 6.77; 2.24–20.47; AA+AC 4.23; 1.44–12.40; p = 0.009). Furthermore, AURKC rs11084490 (GG + CG 1.71; 1.04–2.81; p = 0.033) risk. A combined five SNPs, an detected polymorphism profiles where all combinations contribute higher OR 1.51-fold rs1047972(CT)/rs11084490(CG + GG) 2.29-fold rs1047972(CT)/rs911160(CC) combinations. that different preferentially bind polymorphic sites, indicating be regulated differently depending presence particular allele. Our results revealed (rs1047972 rs911160), (rs2241909 rs2289590) (rs11084490) are a susceptibility. findings also showed effect these may thus significance assessing multiple polymorphisms, jointly. less numerous but ethnically homogeneous Bosnian population, therefore further investigations larger multiethnic groups assessment functional impact needed strengthen findings.