Lack of association between Kawasaki syndrome and Chlamydia pneumoniae infection: an investigation of a Kawasaki syndrome cluster in San Diego County.

摘要: Background. The etiology of Kawasaki syndrome (KS), the leading cause acquired coronary artery disease in children, is unknown. Recent studies have suggested that Chlamydia pneumoniae, a common respiratory pathogen associated with an increased risk heart disease, might lead to KS. Objective. To assess whether KS was elevated having current or antecedent infection C. pneumoniae. Methods. Blood, urine and pharyngeal specimens from patients San Diego County, CA, during period high incidence were analyzed for evidence recent pneumoniae by culture, PCR serology. Specimens collected two control groups, family members age-matched children attending outpatient clinics well child visits, similarly analyzed. Results. Thirteen cases identified. Forty-five controls average three per patient enrolled study. All tested negative presence culture except one blood specimen mother case-patient. Serologic analysis subset revealed no infection; 4 13 adult had IgG titers consistent past exposure Case more likely than illness preceding 2 months (11 vs. 35 45 controls; odds ratio, 1.57; 95% confidence interval, 0.3 11.9). Conclusions. We found