Growth hormone (GH) substitution for one year normalizes elevated GH-binding protein levels in GH-deficient adults secondary to a reduction in body fat. A placebo-controlled trial.

摘要: Summary The high affinity growth hormone binding protein (GHBP) in human serum derives from the extracellular domain of GH receptor. It is well known that fat mass correlates positively to GHBP levels, but it uncertain whether secretory status influences levels. Since body composition change during substitution adult GHD patients, we determined relation between and adults. Twenty-five adults aged 45.0±1.8 years, were examined before after 12 months placebo-controlled (2 IU/m 2 ) a parallel design. A group 27 healthy age-and gender-matched normal-weight provided reference data. participants underwent anthropometric measurements [body index (BMI), waist/hip ratio (W/H)], computer-tomography (CT-scan) femoral abdominal regions, dual-energy X-ray absorptiometry (DEXA-scan), bioimpedance (BIA), as blood sampling. At baseline, levels increased compared controls (1.63±0.14 nmol/l vs 1.12±0.1 nmol/l, P =0.01). During substitution, decreased control subjects. correlated indices adiposity patients at baseline: intra-abdominal ( r =0.54, =0.005), subcutaneous =0.59, =0.41, =0.044), BMI =0.58, =0.002), total (DEXA scan) =0.61,