Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease.

摘要: Introduction. The aim was to highlight the existence of a relationship between vitamin D deficiency, chronic inflammation, and proteinuria, by measuring neutrophil gelatinase associated lipocalin (NGAL) common inflammatory markers after administration paricalcitol, analog, in vivo vitro. Methods. 40 patients with end-stage kidney disease (CKD) secondary hyperparathyroidism healthy subjects were enrolled. Serum calcium, phosphorus, 25(OH)-vitamin D, parathyroid hormone (PTH), erythrocyte sedimentation rate, high-sensitivity C-reactive protein, interleukin- (IL-) 17, IL-6, IL-1β, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), plasmatic urinary NGAL, 24 h albuminuria proteinuria measured before an intravenous bolus paricalcitol (5 mcg). Human peripheral blood mononuclear cells isolated stimulated phytohaemagglutinin. IL-17, TNF-α, IFN-γ culture medium urine collection. Results. lower CKD than controls (p < 0.0001), while higher group 0.0001). In vitro studies showed downregulation Conclusions. regulates immune processes. Further are needed confirm these data order improve treatment patients.