Separation and sample pre-treatment in bioanalysis using monolithic phases: A review.

摘要: In order to support drug discovery and development studies within the pharmaceutical industry there has been an increased use of innovative bioanalytical assays associated analytical technology. Performing quantitative bioanalysis in a variety biological matrices can also involve sample preparation techniques, complex HLPC column switching microfluidic systems. Development for diverse therapeutic agents biomatrices, such as plasma urine, be very technically challenging obtain sensitivity, speed specificity required. This challenge focuses on quantification drugs metabolites at low concentration levels, excess matrix high-throughput manner. One area wide interest is application monolithic phases where emerging technology implemented successfully. review presents overview setting, including challenges that need overcome; synthesis, applicability (with emphasis polymer-based phases); currently available techniques approaches; future possibilities these phases.