Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern.
作者： Reza Saghiri , Niloufar Ghashghai , Shafieh Movaseghi , Pegah Poursharifi , Shohreh Jalilfar
DOI: 10.1007/S00296-011-1836-8
关键词: Case-control study 、 Young adult 、 Lupus erythematosus 、 Internal medicine 、 Rheumatology 、 Medicine 、 Severity of illness 、 Adenosine deaminase 、 Disease 、 Immune system 、 Immunology
摘要: Adenosine deaminase (ADA) plays a crucial role in the development and maintenance of normal immune system. So, any immunological imbalances could associate with its altered activity serum. This study evaluated total ADA isoenzymes serum 45 patients systemic lupus erythematosus (SLE). Included were 23 active SLE, 22 during inactive phase disease, healthy subjects. Our results provided evidence that significantly elevated SLE is correlated mainly increased ADA2 level. The highest mean relapse disease be an indication to macrophages, main source ADA2. It might concluded analysis used as useful non-invasive diagnostic tool evaluation severity.
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