Plasma endogenous opioids and dexamethasone suppression test in depression.
作者： Jorma Kärkkäinen , Timo Laatikainen , Hannu Naukkarinen , Katariina Salminen , Johan Spoov
DOI: 10.1016/0165-1781(87)90072-2
关键词: Opioid 、 Hospital patients 、 Dexamethasone suppression test 、 Dexamethasone 、 Endocrinology 、 Plasma levels 、 Endogenous opioid 、 Depression (differential diagnoses) 、 Internal medicine 、 Medicine 、 Endorphins
摘要: Abstract Plasma levels of β-endorphin plus β-lipotropin were determined in 35 hospital patients with depression and 23 controls before after administration 1 mg dexamethasone (dxm). Dxm suppressed opioid secretion both groups. The the significantly higher than those dxm. All cortisol suppressors. Among post-dxm nonsuppressors ( n =14) suppressors =21). A significant correlation between was found patients. There a association use neuroleptics high levels, but difference not explained by effect any single class drugs. results support concept hypersecretion corticotropin-releasing factor depression.
elsevier.com
sci-hub.se 参考文章(34)
Bernard J. Carroll, A Specific Laboratory Test for the Diagnosis of Melancholia Archives of General Psychiatry. ,vol. 38, pp. 15- 22 ,(1981) , 10.1001/ARCHPSYC.1981.01780260017001
T Laatikainen, K Salminen, U H Stenman, J Leppäluoto, Determination of plasma beta-endorphin and beta-lipotropin by cation-exchange liquid chromatography and radioimmunoassay. Clinical Chemistry. ,vol. 31, pp. 134- 136 ,(1985) , 10.1093/CLINCHEM/31.1.134
S. Govoni, G. Pasinetti, M.R. Inzoli, R. Rozzini, M. Trabucchi, Correlation between beta-endorphin/beta-lipotropin-immunoreactivity and cortisol plasma concentrations Life Sciences. ,vol. 35, pp. 2549- 2552 ,(1984) , 10.1016/0024-3205(84)90442-9
J. L. Nuller, M. N. Ostroumova, Resistance to inhibiting effect of dexamethasone in patients with endogenous depression Acta Psychiatrica Scandinavica. ,vol. 61, pp. 169- 177 ,(1980) , 10.1111/J.1600-0447.1980.TB00576.X
C. Nemeroff, E Widerlov, G Bissette, H Walleus, I Karlsson, K Eklund, C. Kilts, P. Loosen, W Vale, Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients Science. ,vol. 226, pp. 1342- 1344 ,(1984) , 10.1126/SCIENCE.6334362
Florian Holsboer, Helmuth G. Doerr, Armand Gerken, Otto A. Müller, Wolfgang G. Sippell, Cortisol, 11-deoxycortisol, and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers Psychiatry Research. ,vol. 11, pp. 15- 23 ,(1984) , 10.1016/0165-1781(84)90104-5
Robert MA Hirschfeld, Stephen H Koslow, David J Kupfer, The clinical utility of the dexamethasone suppression test in psychiatry. Summary of a National Institute of Mental Health workshop JAMA: The Journal of the American Medical Association. ,vol. 250, pp. 2172- 2174 ,(1983) , 10.1001/JAMA.250.16.2172
James C. Ritchie, Plasma Cortisol Determination for the Dexamethasone Suppression Test Archives of General Psychiatry. ,vol. 42, pp. 493- 497 ,(1985) , 10.1001/ARCHPSYC.1985.01790280075007
Sidney Siegel, Nonparametric statistics for the behavioral sciences ,(1956)
Max Schmauss, Helmfried E. Klein, Wolfram Bender, Hermann Mayr, Alois Niederschweiberer, The DST and its relationship to psychiatric diagnosis, symptoms and treatment outcome. British Journal of Psychiatry. ,vol. 145, pp. 591- 599 ,(1984) , 10.1192/BJP.145.6.591