SUVmax of FDG-PET correlates with the effects of neoadjuvant chemoradiotherapy for oral squamous cell carcinoma
作者： Miyawaki
DOI: 10.3892/OR_00000751
关键词: Immunohistochemistry 、 Internal medicine 、 Chemosensitivity assay 、 Vascular endothelial growth factor 、 Cancer 、 Pathology 、 Medicine 、 Oncology 、 Biopsy 、 Cisplatin 、 Standardized uptake value 、 Chemoradiotherapy 、 Cancer research 、 General Medicine
摘要: The aim of this study was to analyze the relationship between maximum standardized uptake value (SUVmax) 18F-fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) and effects neoadjuvant chemoradiotherapy in oral squamous cell carcinoma (OSCC), identify possible biological background association. Thirty-seven patients with OSCC, who underwent preoperative FDG-PET followed by cancer treatment chemoradiotherapy, were enrolled study. various histological following compared SUVmax primary OSCC. These also immunohistochemical staining score hypoxia-inducible factor-1alpha (HIF-1alpha), glucose membrane transporter (GLUT)-1 vascular endothelial growth factor (VEGF) biopsy specimen. Furthermore, we analyzed chemosensitivity KB-3-1 cells cisplatin under hypoxic conditions using MTT assay. A negative correlation observed (p<0.01). correlated HIF-1alpha (p<0.03), but not GLUT-1 VEGF. mean highly effective group 2.7+/-1.1, which significantly lower than that (3.7+/-0.9) poorly (p<0.05). assay revealed chemoresistant a condition In conclusion, is effectiveness Our clinical experimental analyses further suggest association upregulation chemoradiosensitivity SCC cells.
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