Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1α gene
作者： Yonglei Liu , Ling Wei , Xingwu Wang , Jinming Yu , Xianrang Song
DOI: 10.1007/S00280-006-0224-7
关键词: Gene silencing 、 Hypoxia-inducible factors 、 Transfection 、 Biology 、 Molecular biology 、 Cisplatin 、 Doxorubicin 、 A549 cell 、 RNA interference 、 Hypoxia-Inducible Factor 1-Alpha
摘要: … HIF-1α RNA interference (RNAi) … cell lines, SPCA1 and A549 with HIF-1α specific RNAi lentiviral vectors as well as controls. HIF-1α silenced cells [SPCA1/HIF-1α(-) and A549/HIF-1α(-)] …
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