(18)F-FDG uptake on PET correlates with biological potential in early oral squamous cell carcinoma.
作者： Yuki Yokobori , Minoru Toyoda , Koichi Sakakura , Kyoichi Kaira , Yoshito Tsushima
DOI: 10.3109/00016489.2014.969385
关键词:
摘要: AbstractConclusion: The maximum standardized uptake value (SUVmax) of early oral squamous cell carcinoma (OSCC) may have a role as an imaging biomarker for assessment malignant potential, including metabolism and angiogenesis. Objective: usefulness 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been proven in various cancers, OSCC. Moreover, several carcinomas, the SUVmax tumor shown to correlate with histological type, stage, differentiation, prognosis. Here, we investigated whether OSCC was associated biological features. Methods: Twenty-seven patients newly diagnosed who underwent preoperative FDG-PET curative surgical resection were included this study. Tumor sections stained by immunohistochemistry glucose transporter 1 (GLUT1), L-type amino acid (LAT1), CD98, microvessels (CD34), proliferation marker (Ki-67), cycle regulator (p53). ...
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