Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs
作者： Chenhong Wang , Kuo Zhang , Heran Wang , Shanshan Xu , Charles C. Han
DOI: 10.1016/J.POLYMER.2015.02.001
关键词: Composite material 、 In vitro 、 Biocompatibility 、 Ethylene glycol 、 In vivo 、 Biomedical engineering 、 Materials science 、 Post surgical 、 Wound healing 、 Biodegradation 、 Glycolic acid
摘要: Study of the degradation behavior implants is crucial importance in biomedical fields before practical applications. In this study, degradability poly (DL-lactic-co-glycolic acid) (PDLGA)/poly (DL-lactide)-block-poly (ethylene glycol) (PDLA-b-PEG) scaffolds was evaluated both vitro and vivo. fibrous showed that highly porous structure facilitated diffusion soluble degraded products out scaffolds. The electrospun could maintain structural integrity morphology for 8 weeks during wound healing process When implanted vivo, had good biocompatibility faster than vitro. Long term study rats were totally absorbed. Faster pigs might due to surgical condition difference physiological environment between pigs, such as area, hemorrhage, local motion inflammatory reaction. interaction surrounding tissues would also influence implants. (C) 2015 Elsevier Ltd. All rights reserved.
elsevier.com
core.ac.uk 
sci-hub.se 参考文章(40)
Karen Fu, Daniel W. Pack, Alexander M. Klibanov, Robert Langer, Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres Pharmaceutical Research. ,vol. 17, pp. 100- 106 ,(2000) , 10.1023/A:1007582911958
David Putnam, Drug delivery: the heart of the matter. Nature Materials. ,vol. 7, pp. 836- 837 ,(2008) , 10.1038/NMAT2309
Keiji Numata, Anna Finne-Wistrand, Ann-Christine Albertsson, Yoshiharu Doi, Hideki Abe, Enzymatic degradation of monolayer for poly(lactide) revealed by real-time atomic force microscopy: effects of stereochemical structure, molecular weight, and molecular branches on hydrolysis rates. Biomacromolecules. ,vol. 9, pp. 2180- 2185 ,(2008) , 10.1021/BM800281D
J Štembírek, M Kyllar, I Putnová, L Stehlík, M Buchtová, The pig as an experimental model for clinical craniofacial research Laboratory Animals. ,vol. 46, pp. 269- 279 ,(2012) , 10.1258/LA.2012.012062
Jannine K Patterson, Xin Gen Lei, Dennis D Miller, None, The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption Experimental Biology and Medicine. ,vol. 233, pp. 651- 664 ,(2008) , 10.3181/0709-MR-262
Taiyo Yoshioka, Naoki Kawazoe, Tetsuya Tateishi, Guoping Chen, In vitro evaluation of biodegradation of poly(lactic-co-glycolic acid) sponges. Biomaterials. ,vol. 29, pp. 3438- 3443 ,(2008) , 10.1016/J.BIOMATERIALS.2008.04.011
Tae Gwan Park, Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition Biomaterials. ,vol. 16, pp. 1123- 1130 ,(1995) , 10.1016/0142-9612(95)93575-X
ML Houchin, SA Neuenswander, EM Topp, None, Effect of excipients on PLGA film degradation and the stability of an incorporated peptide Journal of Controlled Release. ,vol. 117, pp. 413- 420 ,(2007) , 10.1016/J.JCONREL.2006.11.023
Sofia Regnell Andersson, Minna Hakkarainen, Ann-Christine Albertsson, Tuning the Polylactide Hydrolysis Rate by Plasticizer Architecture and Hydrophilicity without Introducing New Migrants Biomacromolecules. ,vol. 11, pp. 3617- 3623 ,(2010) , 10.1021/BM101075P
Travis J. Sill, Horst A. von Recum, Electrospinning: Applications in drug delivery and tissue engineering Biomaterials. ,vol. 29, pp. 1989- 2006 ,(2008) , 10.1016/J.BIOMATERIALS.2008.01.011