Adult Acute Lymphoblastic Leukemia: Limitations of Intensification of Therapy in a Developing Country
作者： Punit Jain , Anu Korula , Prashant Deshpande , Nisham PN , Ansu Abu Alex
DOI: 10.1200/JGO.17.00014
关键词: Cyclophosphamide 、 Adult Acute Lymphoblastic Leukemia 、 Chemotherapy 、 Medicine 、 Retrospective cohort study 、 Vincristine 、 Regimen 、 Cohort 、 Internal medicine 、 Survival rate
摘要: PurposeLimited data exist on intensifying chemotherapy regimens in the treatment of adult acute lymphoblastic leukemia (ALL) outside setting a clinical trial.Materials and MethodsRetrospectively, from 507 consecutive adults (age ≥ 15 years) with diagnosis ALL treated at our center were analyzed. Standard-risk (SR) patients offered modified German Multicenter (GMALL) regimen, whereas high-risk (HR) intensification therapy hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone (HCVAD). Because resource constraints, proportion HR opted to receive same regimen as used for SR patients.ResultsThere 344 (67.8%) 163 (32.2%) diagnosis. Among patients, 53 (32.5%) HCVAD regimen. The cohort showed superior 5-year event-free survival rate compared (47.3% v 23.6%, respectively; P < .00...
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