PGC1α confers specificity-metabolic stress and p53-dependent transcription.
作者： Mario Cioce , Giovanni Blandino
DOI: 10.1016/J.MOLCEL.2011.11.003
关键词: Metabolic Stress 、 Cell 、 Transcription (biology) 、 Transcriptional activity 、 Gene 、 Biology 、 Cell biology
摘要: In this issue of Molecular Cell , Sen et al. (2011) report the involvement PGC1α in modulating transcriptional activity p53 metabolically challenged cells. They provide important insights into mechanisms linking length and strength metabolic stress stimuli to specific activation target genes.
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