Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

作者: Giovanni Blandino , Mariacristina Valerio , Mario Cioce , Federica Mori , Luca Casadei

DOI: 10.1038/NCOMMS1859

关键词:

摘要: Metformin is used to treat diabetes and its use has been associated with reduced cancer incidence, but the mechanism unclear. In this study, metformin shown alter microRNA expression including an increase in mir-33a, which decreases of oncogene c-Myc.

参考文章(47)
Erich Eigenbrodt, Sybille Mazurek, The tumor metabolome. Anticancer Research. ,vol. 23, pp. 1149- 1154 ,(2003)
H. Wallberg-Henriksson, T. Sonnenfeld, A. Thorne, D. Galuska, J. Zierath, Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle. Diabète & métabolisme. ,vol. 17, pp. 159- 163 ,(1991)
Benoit Viollet, Fabrizio Andreelli, AMP-Activated Protein Kinase and Metabolic Control Diabetes - Perspectives in Drug Therapy. ,vol. 203, pp. 303- 330 ,(2011) , 10.1007/978-3-642-17214-4_13
Mario Cioce, Giovanni Blandino, PGC1α confers specificity-metabolic stress and p53-dependent transcription. Molecular Cell. ,vol. 44, pp. 515- 516 ,(2011) , 10.1016/J.MOLCEL.2011.11.003
Klearchos K Papas, Lei Sun, Eric S Roos, John S Gounarides, Michael Shapiro, Carlo M Nalin, Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression. FEBS Letters. ,vol. 446, pp. 338- 342 ,(1999) , 10.1016/S0014-5793(99)00240-9
Kristine Glunde, Ellen Ackerstaff, Noriko Mori, Michael A. Jacobs, Zaver M. Bhujwalla, Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. Molecular Pharmaceutics. ,vol. 3, pp. 496- 506 ,(2006) , 10.1021/MP060067E
John C. Lindon, Jeremy K. Nicholson, Spectroscopic and Statistical Techniques for Information Recovery in Metabonomics and Metabolomics Reviews in Analytical Chemistry. ,vol. 1, pp. 45- 69 ,(2008) , 10.1146/ANNUREV.ANCHEM.1.031207.113026
Irina N. Alimova, Bolin Liu, Zeying Fan, Susan M. Edgerton, Thomas Dillon, Stuart E. Lind, Ann D. Thor, Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro Cell Cycle. ,vol. 8, pp. 909- 915 ,(2009) , 10.4161/CC.8.6.7933
Yoko Karube, Hisaaki Tanaka, Hirotaka Osada, Shuta Tomida, Yoshio Tatematsu, Kiyoshi Yanagisawa, Yasushi Yatabe, Junichi Takamizawa, Shinichiro Miyoshi, Tetsuya Mitsudomi, Takashi Takahashi, Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Science. ,vol. 96, pp. 111- 115 ,(2005) , 10.1111/J.1349-7006.2005.00015.X