Determinants of Hypercapnia in Occlusive Sleep Apnea Syndrome
作者： Judith A. Leech , Ergün Önal , Paul Baer , Melvin Lopata
关键词: Respiratory system 、 Pulmonary function testing 、 Respiratory disease 、 Sleep apnea 、 Sleep disorder 、 Anesthesia 、 Medicine 、 Hypoxemia 、 Apnea 、 Hypercapnia 、 Critical Care and Intensive Care Medicine 、 Pulmonary and Respiratory Medicine 、 Cardiology and Cardiovascular Medicine
摘要: To assess the relative contributions of age, gender, obesity, pulmonary function, and severity sleep-induced respiratory abnormalities to development alveolar hypoventilation in patients with occlusive sleep apnea syndrome, prospective data from 111 were analyzed by stepwise logistic multiple regression techniques. The significant variables a model predicting presence hypercapnia daytime arterial oxygen pressure (PaO 2 ; p ) revealed contribution PaO , apnea-plus-hypopnea index (AHI), percent predicted forced vital capacity (r = O.56; related only. These results suggest that hypoxemia, mechanical impairment system due obesity or obstructive airway disease (or both), as assessed AHI contribute carbon dioxide retention multifactorial fashion.
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