IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration
作者： Suyong Choi , Narendra Thapa , Andrew C Hedman , Zhigang Li , David B Sacks
关键词: Integrin 、 Phosphatidylinositol 、 IQGAP1 、 Phosphatidylinositol 4,5-bisphosphate 、 Cytoskeleton 、 Biology 、 Effector 、 Leading edge membrane 、 Cell migration 、 Cell biology
摘要: Phosphatidylinositol 4,5 bisphosphate (PIP2) is a key lipid messenger for regulation of cell migration. PIP2 modulates many effectors, but the specificity signalling can be defined by interactions PIP2-generating enzymes with effectors. Here, we show that type Iγ phosphatidylinositol 4-phosphate 5-kinase (PIPKIγ) interacts cytoskeleton regulator, IQGAP1, and IQGAP1 function in We reveal PIPKIγ required recruitment to leading edge membrane response integrin or growth factor receptor activation. Moreover, effector directly binds through polybasic motif binding activates facilitating actin polymerization. mutants lack lose ability control directional Collectively, these data synergy between
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