Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells.

作者: Patricia J. Keely

DOI: 10.1016/S0076-6879(01)33061-6

关键词:

摘要: There has been much interest in how Ras and Rho proteins affect cell migration invasion. Studies of the molecular mechanisms signaling pathways that are involved will be aided by development use relevant model systems simple vitro assays. While a complete understanding metastasis ultimately need to employ vivo studies, invasion assays presented here good initial assessments events metastatic cascade.

参考文章(11)
Patricia J. Keely, John K. Westwick, Ian P. Whitehead, Channing J. Der, Leslie V. Parise, Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K Nature. ,vol. 390, pp. 632- 636 ,(1997) , 10.1038/37656
Juliet Lee, Akira Ishihara, Gerry Oxford, Barry Johnson, Ken Jacobson, Regulation of cell movement is mediated by stretch-activated calcium channels Nature. ,vol. 400, pp. 382- 386 ,(1999) , 10.1038/22578
Seog-Nyeon Bae, Gloria Arand, Hala Azzam, Prasit Pavasant, Jeffrey Torri, Thomas L. Frandsen, Erik W. Thompson, Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Research and Treatment. ,vol. 24, pp. 241- 255 ,(1993) , 10.1007/BF01833264
Patricia J. Keely, Elena V. Rusyn, Adrienne D. Cox, Leslie V. Parise, R-Ras Signals through Specific Integrin α Cytoplasmic Domains to Promote Migration and Invasion of Breast Epithelial Cells Journal of Cell Biology. ,vol. 145, pp. 1077- 1088 ,(1999) , 10.1083/JCB.145.5.1077
Paul Peter Rosen, Debra Ernsberger, Low-grade adenosquamous carcinoma. A variant of metaplastic mammary carcinoma. The American Journal of Surgical Pathology. ,vol. 11, pp. 351- 358 ,(1987) , 10.1097/00000478-198705000-00003
H.C. Freake, C. Marcocci, J. Iwasaki, I. MacIntyre, 1,25-dihydroxyvitamin D3 specifically binds to a human breast cancer cell line (T47D) and stimulates growth Biochemical and Biophysical Research Communications. ,vol. 101, pp. 1131- 1138 ,(1981) , 10.1016/0006-291X(81)91565-5
Fattaneh A. Tavassoli, Pathology of the breast ,(1992)
A E Faassen, J A Schrager, D J Klein, T R Oegema, J R Couchman, J B McCarthy, A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion. Journal of Cell Biology. ,vol. 116, pp. 521- 531 ,(1992) , 10.1083/JCB.116.2.521
Samuel A. Santoro, Mary M. Zutter, Patricia J. Keely, Alan M. Fong, Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells Journal of Cell Science. ,vol. 108, pp. 595- 607 ,(1995) , 10.1242/JCS.108.2.595
Anna Huttenlocher, Margot Lakonishok, Melissa Kinder, Stanley Wu, Tho Truong, Karen A. Knudsen, Alan F. Horwitz, Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity Journal of Cell Biology. ,vol. 141, pp. 515- 526 ,(1998) , 10.1083/JCB.141.2.515