Maintaining corneal integrity how the "window" stays clear.

摘要: Abstract The anterior surface of the eye is composed cornea, conjunctiva, and zonebetween two called limbus. cornea must maintain optical clarity to retain good vision. However, ocular vulnerable trauma, microbial infection, exposure environmental toxins. This places especially, at risk for disruptions epithelial barrier subsequent immunopathological events. Cell-cell cell-matrix attachment junctions incorporating adhesion molecules ensure that remains intact. Protein components basement membrane, including laminins, are vital corneal cells underlying stroma function enhance strength bond between epithelium connective tissue. Epithelial also play an early crucial role in initiation responses should a potentially antigenic molecule enter into deeper tissues. For example, may produce release cytokines such as interleukin-1 (IL-1). delicate balance matrix metalloproteinases (MMPs) tissue inhibitors (TIMPs) central mechanisms regulating dissolution extracellular be consequence infection or wound healing. Adhesion molecules, chemokines, MMPs TIMPs thus participate response immunologic challenge wounding. They involved pathologies associated with genetic diseases, diabetes, vitamin A deficiency. In addition these cellular pathways clinical complications often observed contact lens wear refractive surgeries used improve visual acuity.