The Role of Antimicrobial Peptides at the Ocular Surface

摘要: Antimicrobial peptides (AMPs) such as defensins and cathelicidins are small with broad-spectrum activity against bacteria, fungi viruses. In addition, several AMPs modulate mammalian cell behaviours including migration, proliferation cytokine production. This review describes findings from recent studies showing the presence of various at human ocular surface discusses their mechanism antimicrobial action potential non-microbicidal roles. Corneal conjunctival epithelial cells produce β-defensins cathelicidin LL-37, whereas neutrophils, infiltrating in response to a specific stimulus, supply additional LL-37 well α-defensins. vitro suggest that β-defensin-3 most likely have significant independent activity, while other may act synergistically help protect invading pathogens. Current evidence also supports role for some modulating wound healing responses. Although yet be brought fruition, hold therapeutic agents prophylaxis treatment infection, promotion immune modulation.