twist is a potential oncogene that inhibits apoptosis

摘要: Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis must depend, in part, on compensating mutations that protect from programmed cell death. A functional screen for cDNAs could counteract the proapoptotic effects of myc oncogene identified two related bHLH family members, Twist and Dermo1. Both these proteins inhibited oncogene- p53-dependent expression bypassed p53-induced growth arrest. These correlated with an ability interfere a reporter impair induction p53 target genes response DNA damage. An underlying explanation this observation may be provided by reduce ARF tumor suppressor. affect indirectly through modulation ARF/MDM2/p53 pathway. Consistent role as potential oncoprotein, promoted colony formation E1A/ras-transformed mouse embryo fibroblasts (MEFs) soft agar. Furthermore, was inappropriately expressed 50% rhabdomyosarcomas, arises skeletal muscle precursors fail differentiate. is known block myogenic differentiation. play multiple roles halting terminal differentiation, inhibiting apoptosis, interfering tumor-suppressor