Urinary arsenic and insulin resistance in US adolescents.

摘要: Chronic arsenic exposure has been associated with increased diabetes risk in adults. Insulin resistance (IR) proposed as a mechanism of arsenic-related diabetes. Although limited evidence adults found no association between and IR, the adolescents is largely unknown. We examined urinary insulin US adolescents. Eight hundred thirty five aged 12-19 years, complete data on (total arsenic, inorganic dimethylarsenic acid (DMA)), fasting glucose, key covariates were identified from National Health Nutrition Examination Survey (NHANES) cycles 2003/2004 through 2009/2010. Generalized additive mixed models accounting for intra-cluster correlation arising complex survey design used to estimate updated Homeostasis Model Assessment (HOMA2)-IR each type arsenic. After adjusting potential confounders, including creatinine, sociodemographic factors, BMI, waist circumference, arsenobetaine, was not HOMA2-IR. Interquartile range increases total DMA 1.5% (95% CI: -2.0, 5.2), 1.1% -1.5, 3.8) 0.25% -2.3, 2.9) HOMA2-IR, respectively. In conclusion, despite arsenic's role resistance, our findings do support hypothesis that at levels common contributes Whether higher doses longer duration are required appreciable influence or does act induce needs further investigation.