Intraportal and Intraperitoneal Chemotherapy for Colon Cancer

摘要: Metachronous liver metastases are present at the time of initial diagnosis colorectal cancer in approx 25–30% patients (1). Similarly, is most common and sometimes only site distant failure after potential curative surgical resection (2). Colorectal reach via portal vein such dissemination may occur preoperatively intraoperatively. Operative stress immediate postoperative decrease immune defense, fact, have been shown some experimental models to improve survival malignant cells facilitate their growth (3). Fisher Turnbull discovered tumor mesenteric venous blood 32% (4), 1957, Dukes found evidence spread 17% operative rectal specimens (5). Despite continuing controversies, established seem be fed primarily by hepatic artery, whereas micrometastases likely depend on (6,7). Thus, early regional administration chemotherapeutic agents into (resulting high anticancer drug concentrations) might particularly beneficial, destroying suspected before can take place. Ideally, treatment should commenced shortly primary tumor, because more sensitive a given due shorter cell-cycle time, better accessibility drugs, smaller chance harboring resistance (8,9).