Phase I trial of concurrent intraperitoneal and continuous intravenous infusion of fluorouracil in patients with refractory cancer.
作者： B Reichman , M Markman , T Hakes , N Kemeny , D Kelsen
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摘要: In an effort to maximize both local-regional and systemic drug exposure tumor in the peritoneal cavity, a phase I study was conducted that examined simultaneous daily intraperitoneal (IP) continuous intravenous infusion (CVI) of fluorouracil (5-FU) 32 patients with refractory cancer. IP 5-FU administered at 1,000 mg/d concurrent by CVI mg/m2/d for four consecutive days well tolerated. One patient primary gastrointestinal (GI) malignancy minimal volume disease experienced surgically defined complete remission. theory, this regimen may demonstrate clinical utility as adjuvant treatment certain GI malignancies. Future studies are planned setting.
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