Portal Levels and Hepatic Clearance of 5-Fluorouracil after Intraperitoneal Administration in Humans

摘要: Abstract Intrahepatic tumor is a major problem in clinical oncology. While direct intravascular infusions provide high local drug concentrations and variable rates of response, they are limited by technical considerations complications. In this study, we have tested whether portal venous hepatic arterial 5-fluorouracil (5-FUra) can be achieved administering via peritoneal dialysis. Four patients with metastatic colon carcinoma had Tenckhoff catheter surgically implanted. During dialysis therapy 4 mm 5-FUra, simultaneous samples fluid venous, peripheral blood were obtained, 5-FUra determined. Mean peak vein 60 µm exceeded the measured other vessels. Total exposures as concentration × time (mm min) during Exchange 1 were: portal, 3.8 ± 0.65; vein, 0.97 0.44; 0.90 0.32; arterial, 1.1 0.26. 7, total 6.3 1.4; 2.5 1.3; 2.3 1.1; 2.7 .85. The fraction i.p. that exited cavity through system ranged from 0.29 to 1.0. This variation resulted part uncertainty estimating flow gastrointestinal elimination. Calculated extraction was 67% (range, 0.23 0.89). Extrahepatic metabolism demonstrated. Measured compared favorably values predicted pharmacokinetic model for 5-FUra. Dialysis (i.p.) provides means achieving treating both intrahepatic tumor. Further testing route administration warranted.