Methods of the assessment of the effect of drugs on liver blood flow in man.

摘要: The liver is the central metabolic organ of body and therefore volume composition blood perfusing are undoubtedly major determinants hepatocellular function. In past amount flow its regulation was mainly investigated by physiologists most work done in animals (Bradley, 1963; Greenway Stark, 1971). recent years clinicians pharmacologists have paid more attention to problem measurements as it found that drug metabolism can be influenced changes under certain experimental conditions (Ohnhaus, Thorgeirsson, Davies Breckenridge, 1971; Branch, Shand, Wilkinson Nies, 1974). Based on these findings a physiological approach hepatic clearance has been developed which seems very useful predicting kinetics produced variations biological disposition (Wilkinson, 1975; 1975). addition, surgeons started treat portal hypertension occurring disease such cirrhosis portocaval or similar anastomoses, assessed with other parameters function select appropriate patients for surgery (Bircher, Blankart, Halpern, Hacki, Laissue Preisig, 1973). These facts increased tremendously interest clinical methods measurement their limitations order investigate outcome following different operating procedures.