Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow

摘要: Abstract Hepatic plasma flow was assessed with sorbitol (hepatic extraction=0.96) at steady state. After infusion of 50 mg/min for 3 h, total and renal clearances were calculated, the extrarenal clearance obtained by taking difference between two. In normal volunteers, mean (±SD) 10.6 ± 2.1 ml/min · kg. patients various liver diseases, it correlated more closely to fractional indocyanine green (r = 0.83, n=57) than galactose elimination capacity 0.66, n=55). vein catheterization showed that hepatic extraction always much higher green; there no evidence extrahepatic, elimination. On basis these findings, is kinetically superior and, although noninvasively determined state may not be equal flow, least regarded as a measure parenchymal flow.